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Biology of vascular endothelial growth factors.

Identifieur interne : 007A32 ( Main/Exploration ); précédent : 007A31; suivant : 007A33

Biology of vascular endothelial growth factors.

Auteurs : Himadri Roy [Finlande] ; Shalini Bhardwaj ; Seppo Yl Herttuala

Source :

RBID : pubmed:16631753

Descripteurs français

English descriptors

Abstract

Angiogenesis is the process by which new blood vessels are formed from existing vessels. The vascular endothelial growth factors (VEGFs) are considered as key molecules in the process of angiogenesis. The VEGF family currently includes VEGF-A, -B, -C, -D, -E, -F and placenta growth factor (PlGF), that bind in a distinct pattern to three structurally related receptor tyrosine kinases, denoted VEGF receptor-1, -2, and -3. VEGF-C and VEGF-D also play a crucial role in the process of lymphangiogenesis. Here, we review the biology of VEGFs and evaluate their role in pathological angiogenesis and lymphangiogenesis.

DOI: 10.1016/j.febslet.2006.03.087
PubMed: 16631753


Affiliations:


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